Description
By (author) Amiji, Mansoor; By (author) Cook Thomas; By (author) Mobley, W. Cary
:
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A complete practice-oriented introduction to physical pharmacy
Written to clearly and simply explain how drugs work, this textbook explores the fundamental physicochemical attributes and processes important for understanding how a drug is transformed into a usable product that is administered to a patient to reach its pharmacological target, and then exists the body.
Applied Physical Pharmacy, Third Edition begins with a review of the key biopharmaceutics concepts of drug liberation, absorption, distribution, metabolism, and excretion. These concepts, and others, set the framework for the subsequent chapters that describe physicochemical properties and process related to the fate of the drug. Other physical pharmacy topics important to drug formulation are discussed in the chapters that follow, which describe dispersal systems, interfacial phenomena, and rheology. The textbook concludes with an overview of the principles of kinetics that are important for understanding the rates at which many of the processes discussed in previous chapters occur.
Chapters in this Third Edition retain the acclaimed learning aids of previous editions, including Learning Objectives, Practice Problems, Key Points, and Clinical Questions. In order to be of greater value to the pharmacy student, more clinical questions have been added, and many tables have been updated with more current products and excipients.
Table of contents:
Contributors
Preface
1. Introduction to Biopharmaceutics
Introduction
Drug Disposition—The Fate of the Drug After Administration
Ladme
Conclusion
Key Point
Clinical Questions
2. States of Matter Related to Pharmaceutical Formulations
Introduction
Intermolecular Forces
States of Matter
Stability of Solids
Acknowledgment
Problems
Answers
Key Points
Clinical Questions
Appendix
3. Physical Properties of Solutions
General Considerations
Concentration Expressions
Classification of Aqueous Solution Systems
Physical Properties of Solutions
Physiologic Applications of Colligative Properties
Isotonic Solutions
Sodium Chloride Equivalent Values (E)
Problems
Answers
Key Points
Clinical Questions
Appendix
4. Ionic Equilibria and Buffers
Electrolytes Versus Nonelectrolytes
Importance of Ionization in Pharmacy
Acids and Bases
Ionization of Water
Ionization of Electrolytes
Ionization of Salts
Buffers
Ionization of Amphoteric Electrolytes
Ionization of Polyprotic Acids
Activity and Activity Coefficient
Acid–Base Titration and Titration Curve
Problems
Answers
Key Points
Clinical Questions
Appendix
Suggested Readings
5. Solubility, Dissolution, and Partitioning
Solubility
Dissolution
Dissolution of Particles
Factors Affecting Drug Dissolution
Partitioning
Solubility Problems
Answers
Dissolution Problems
Answers
Partitioning Problems
Answers
Key Points
Clinical Questions
Appendix
6. Mass Transport
Introduction
Transport Systems
Diffusion Through a Membrane
Significance of Diffusion
Significance of Osmosis
Problems
Answers
Key Points
Clinical Questions
7. Complexation and Protein Binding
Introduction
Types of Complexes
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